Researchers Find Unexpected Cellular Residence for Protein Vital in Neurodevelopment
In Professor Xuecai Ge ’s lab, where UC Merced researchers study how cells talk to each other to develop and differentiate, a recent surprise discovery is lending insight as to how erroneous cell signals lead to disease and birth defects.
Ge and her colleagues zeroed in on a slice of the communication system, the primary cilia, and found a protein called Numb, which they didn’t expect to be there.
Numb facilitates development of the spinal cord and cerebellum during embryonic neurodevelopment.